Jun 01, 2021 · Occludin S490 phosphorylation regulates vascular endothelial growth factor-induced retinal neovascularization Am. J. Pathol. , 186 ( 2016 ) , pp. 2486 - 2499 Article Download PDF View Record in Scopus Google Scholar Chemistry Tree - David A AntonettiLiu X, Dreffs A, Díaz-Coránguez M, et al. (2016) Occludin S490 Phosphorylation Regulates Vascular Endothelial Growth Factor-Induced Retinal Neovascularization. The American Journal of Pathology:Bolinger MT, Ramshekar A, Waldschmidt HV, et al. (2016) Occludin S471 phosphorylation contributes to epithelial monolayer maturation.
Apr 08, 2018 · Occludin is an integral membrane protein with four transmembrane domains that is exclusively localized at tight junction (TJ) strands. Here, we describe the generation and analysi Dr. Thomas Gardner, MD Ann Arbor, MI OphthalmologyOccludin S490 Phosphorylation Regulates Vascular Endothelial Growth Factor-Induced Retinal Neovascularization. Xuwen Liu, Alyssa Dreffs, Mónica Díaz-Coránguez, E. Aaron Runkle, Thomas W. Gardner, Vince A. Chiodo, William W. Hauswirth, David A. Antonetti> ;American Journal of Ischemia-reperfusion injury induces occludin Jan 08, 2014 · Immunohistochemical analysis revealed a rapid increase in occludin Ser490 phosphorylation and loss of Zonula occludens-1 (ZO-1) protein, particularly in arterioles. Ischemia-reperfusion injury also rapidly induced the activation and phosphorylation of vascular endothelial growth factor receptor-2 (VEGFR-2) at tyrosine 1175.
Aug 11, 2009 · Abstract Vascular endothelial Junyeop Lee, Crumbs proteins regulate layered retinal vascular development required for vision, Biochemical and Biophysical Vince A. Chiodo, William W. Hauswirth, David A. Antonetti, Occludin S490 Phosphorylation Regulates Vascular Endothelial Growth FactorInduced Retinal Neovascularization Modulation of Tight Junction Structure and Function by Jan 23, 2012 · They critically regulate vasculogenesis and angiogenesis and have early been identified to induce occludin phosphorylation thereby modulating barrier properties . Although the downstream kinase is not jet identified, by analyzing crude membrane fractionations of bovine retinal endothelial cells (BRECs) +/ VEGF stimulation and by combining mass spectrometry data analyses with Table of Contents page:The American Journal of PathologyAug 09, 2016 · Occludin S490 Phosphorylation Regulates Vascular Endothelial Growth FactorInduced Retinal Neovascularization. Xuwen Liu, Alyssa Dreffs, Monica Díaz-Coránguez, Vince A. Chiodo, William W. Hauswirth, David A. Antonetti
Jul 03, 2012 · Y474 phosphorylation is associated with binding p85 of phosphatidyl inositol 3-kinase at the leading edge of migrating cells while S490 and S508 are associated with vascular permeability after VEGF treatment or HIV encephalitis . Our results suggest a role for S471 phosphorylation Vascular eion of permeability-resistant occludin Here, we investigate the role of tight junction protein occludin phosphorylation at S490 in modulating barrier properties and its impact on visual function. Conditional vascular eion of the phosphorylation resistant Ser490 to Ala (S490A) form of occludin preserved tight junction organization and reduced VEGF-induced permeability and edema formation after intra-ocular injection.